Abstract
SummaryThe vascoconstrictor potency of angiotensin on the rabbit ear was greatly reduced by sectioning the ear so that only the proximal portion remained, or by removal of the entire vasculature other than a small segment of the central artery immediately distal to the site of cannulation.The above procedure had much less effect on the vasoconstrictor potencies of noradrenaline and histamine.The findings indicate that angiotensin's action on the ear vessels is mediated largely beyond the larger resistance vessels such as the central artery, whereas noradrenaline and histamine constrict both large and small resistance vessels.It is concluded that comparison of drug effects on the whole ear and on the central artery alone provides a useful guide to their sites of action on the ear vasculature.
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