Abstract
The effects of treatment with hydrochlorothiazide 50 mg twice daily were compared with those of frusemide 40 mg twice daily in a double-blind study involving 20 hypertensive outpatients. Both treatments cause significant reductions of blood-pressure and plasma potassium concentration, but, at the doses used, the reductions produced by hydrochlorothiazide were significantly greater than those produced by frusemide. Both treatments caused significant increases in plasma urea and uric acid concentrations. There were no significant changes in whole-body potassium content, glucose tolerance, or serum insulin response to orally administered glucose.
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