Abstract
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Highlights
Prostate cancer (PC) is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths [1]
We compared the expression of Prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) according to RKIP among (PSA+, PSMA+) profile
Consistent with the correlation between PSA, PSMA expression, and tumor stage, it was revealed that PSA on tissue level was inverse related to Gleason grade, whereas increased levels of PSMA are associated with high-grade prostate cancers [17, 18]
Summary
Prostate cancer (PC) is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths [1]. Prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA) have been identified as the most promising biomarkers in diagnosis and treatment of PC [3, 4]. It has been well known that the NF-κB (p50/65) pathway plays a critical role in prostate cell development and progression of various human malignancies [9, 10]. We initially analysed the expression of PSA and PSMA according to RKIP and investigated the components of Ras/Raf-1/MEK/ERK, NF-κB (p50/p65), and Akt (T308/S473) pathways in conjunction with PSA and PSMA according to RKIP in human cancerous prostate with (PSA+, PSMA+) profile to assess the biological characters of this mostly immunoexpressed PC profile
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