Abstract
The importance of the gastrointestinal microflora in the metabolism of nicotinic acid and nicotinamide has been investigated using 7- 14C-labeled vitamin forms. The CO 2 released from C-7 of the vitamins forms has been shown to result from microbial metabolism. The distribution of label in urinary metabolites was essentially unchanged in germ-free animals, indicating that the tissues of the rat are capable of metabolizing both vitamin forms in a normal manner without microbial assistance.
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