A Comparative Study of the Effectiveness of Prophylactic Antibiotics With or Without Additional Post-op Antibiotics Administration in Cesarean Section Patients for Prevention of Post-op Infection in a Private Hospital

Abstract

OBJECTIVES: To assess the effectiveness of prophylactic antibiotics with or without additional post-op antibiotics on infectious complications in women undergoing cesarean section. MATERIALS AND METHODS: Retrospective chart review of cesarean section patients at Bangkok Hospital Chiang Mai between 1 January 2016 to 31 December 2018 was carried out. Women at 37-42 weeks’ gestational age who underwent cesarean section and received prophylactic antibiotics with or without additional post-op antibiotic administration were reviewed. They were divided into 2 groups: those who received post-delivery antibiotic vs those who did not. To compare post cesarean delivery infection rate from the delivery day until 6 weeks after. The primary end point is post cesarean section infection from delivery to 6 weeks’ post-operative RESULTS: 481 women received prophylactic antibiotic prior to delivery by cesarean section. 46 were excluded 32 due to being less than 37 weeks’ gestational age, 3 received antibiotics a week prior to delivery, 11 with history of allergic reaction to penicillin or cephalosporin. So, only 435 women met these research study criteria. Within these, 170 cases (39.1%) received additional antibiotics after cesarean delivery, 265 cases (60.9%) didn’t receive antibiotics after cesarean delivery. 20% of prophylactic antibiotic patients only spent more than 60 minutes in the operation room, while 55.29% of those with additional antibiotic post-op did so. 4 (2.4%) cases of additional antibiotic post-op group had post-delivery infection. While 2 (0.8%) cases of patient without additional post-op antibiotic developed infection. CONCLUSION: Additional post-op antibiotics didn’t decrease the incidence of post-delivery infections.