Abstract
Purpose: To determine the analgesic effects of sevoflurane (Sev) and propofol (Pro) in children whounderwent otolaryngology surgical procedures, and their post-operative conditions.Methods: A total of 62 (ASA I or ASA II) pre-medicated children who were about to undergootolaryngology surgical procedures were chosen and divided equally into Sev and Pro groups, with 31patients per group. During the surgical procedure, Sev was administered via a mask, while Pro wasgiven i.v. Each anesthesia was followed with fentanyl administration.Results: Pain scores such as verbal rating scale (VRS) and visual analogue scale (VAS) were slightlylower in Sev group than in Pro group. However, post-operative conditions such as emergence delirium(ED) and emergence agitation (EA) were significantly elevated in Sev group, when compared to Progroup (p < 0.05). In addition, patients in Sev group had higher levels of hemodynamic parameters(blood pressure), and much higher number of adverse events than those in Pro group. Thus, the overallsatisfaction score and recovery characteristics, i.e., hospitalization time and recovery were slightlybetter in Pro-anesthetized children than in those given Sev.Conclusion: These results suggest that except for pain score, Pro-anesthetized children fared better interms of speedy recovery and reduced adverse effects than those given Pro. Thus, Pro may berecommended as general anaesthetic for children undergoing otolaryngology surgical procedures.Keywords: Sevoflurane, Propofol, Pain score, Emergence agitation, Otolaryngology
Highlights
Several reports indicate that combination of various agents such as analgesics, hemodynamics, stabilizers, muscle relaxants and hypnotics in proper proportion produces adequate analgesic effect and speedy recovery, and reduces adverse effects [1,2]
Sevoflurane (Sev) or ultane is a poorly-soluble inhaled anaesthesia that is highly recommended as general anaesthesia for children or kids because apart from its pleasant smell, it is associated with good early recovery and adequate hemodynamic stabilizing properties [5,6]
Data are expressed as mean ± standard deviation (SD); *p < 0.05; #p < 0.01, Sev vs Pro demerits which formed the basis of the present study aimed at comparison of their analgesic and postoperative complications in children who underwent otolaryngology surgical procedures
Summary
Several reports indicate that combination of various agents (multimodal analgesics) such as analgesics, hemodynamics, stabilizers, muscle relaxants and hypnotics in proper proportion produces adequate analgesic effect and speedy recovery, and reduces adverse effects [1,2]. The present trial was designed to compare the analgesic effects of Pro and Sev by measuring visual analogue scale (VAS) and verbal rating scale (VRS) as well as post-operative conditions such as anaesthesia emergence delirium (PAED) scale and hemodynamic parameters (blood pressure and heart rate) in children who underwent otolaryngology surgical procedures involving tonsillectomy, adenoidectomy, and ear tube (tympanostomy). The overall hospital stay for each child was recorded Hemodynamic parameters such as diastolic blood pressure (DBP), mean arterial blood pressure (MAP), systolic blood pressure (SBP) and heart rate (HR) were monitored during surgical procedure and recorded only in the recovery room (5 min after opening of eyes).
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