Abstract
Background: Diabetes mellitus is a chronic disorder and its association with an increased propensity of infection has in general, been well recognized. Clinical data on the association of diabetes mellitus with common infections are virtually lacking, not conclusive and often biased. Aims & Objective: The present study was done to determine profile of various infections with their etiological agents and antibiotic sensitivity pattern among diabetic and non-diabetic patients. Materials and Methods: A Cross-sectional descriptive study was conducted at a tertiary care hospital in India. The study included 100 diabetic and 100 non-diabetic patients with suspected infections and samples were processed for culture and antibiotic sensitivity testing. The analysis was done using the software Statistical Package for Social Scientists (SPSS) 15.0. Results: Infections encountered in diabetics were urinary tract infection (UTI) (32%), skin and soft tissue infection (12%), lower respiratory tract infection (LRTI) (8%), septicemia (3%) and ascites (1%) whereas prevalence of various infections in non-diabetic patients were UTI (13%), skin and soft tissue infection (19%), LRTI (10%), septicemia (2%), acute appendicitis (1%) and enteric fever (1%). Among various infections, prevalence of urinary tract infection was significantly higher in diabetics (32%) than non-diabetics (13%) (P value = 0.001). Resistance to fluoroquinolones among urinary isolates of E.coli was significantly higher (89.5%) in diabetic patients compared to (50%) in non-diabetic patients (P value = 0.02). Conclusion: Prevalence of UTI was significantly higher in diabetics than non-diabetics where E.coli was the predominant pathogen in both the group of patients. Fluoroquinolones resistance was more common in diabetic than non – diabetics. We would like to recommend restriction of empirical use of fluoroquinolones in diabetic patients. Carbapenem, Amikacin, Piperacillin-tazobactum and Nitrofurantoin still has acceptable sensitivity against uropathogenic E. coli in both the group of patients and can still be used in treatment failure.
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