Abstract
Aim: Our aim of this randomized & prospective clinical study was to investigate and compare the efficacy of palonosetron HCl and granisetron HCl to prevent postoperative nausea and vomiting after gynaecological surgery. Method: Fifty female patients of ASA grade I and II in between 18-60 years of age posted for elective gynaecological surgery were randomly divided into two groups containing 25 patients each. Before induction of anaesthesia group P received bolus dose of palonosetron 75 mcg and group G received bolus dose of granisetron 2.5 mg intravenously slowly over a period of 30 seconds. Result: In the postoperative period (0-3 hrs), the incidence of complete response (no postoperative nausea & vomiting, no rescue medication) was 88% with palonosetron and 76% with granisetron (p value-0.46). During 3-24 hrs postoperatively the incidence was 92% with palonosetron and 80% with granisetron (p value-0.417). During 24-48 hrs postoperatively the incidence was 92 % with palonosetron and 60 % with granisetron (p value-0.018). During 48-72 hrs incidence was statistically insignificant (p value-0.1284). Insignificant incidence of side effects between the groups was found. Conclusion: Palonosetron is more potent and long acting than granisetron for the prevention of post operative nausea & vomiting after gynaecological surgery.
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