Abstract
A new analgetic tablet, designated as the P-tablet, has been compared with aspirin and two well-known analgetic tablets. Each tablet contains a source of salicylate ion and the dose of each drug has been calculated on the basis of salicylate equivalents; this permitted a fair evaluation of the resultant plasma-salicylate levels. Plasma-salicylate levels have been used as an index of their therapeutic activity. The influence of the various components of each tablet on the rate of absorption has, in effect, been compared to the rate of absorption of aspirin alone. The plasma- salicylate concentrations have been determined colorimetrically and evaluated by significance tests for multiple contrasts in the analysis of variance. The analyses show that significantly higher plasma-salicylate levels are obtained from the P-tablet than from Bufferin®, Anacin® or aspirin, at five and ten minutes after administration.
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