Abstract
AbstractDirect and ultrasensitive detection of nanoscale objects is of great importance for materials science and biomedical application. Here, a printed single nanoparticle array‐based coloration biochip is developed for direct visualizing nanoscale objects with the microscopy image. Arising from the scattering cross section induced Mie scattering enhancement, the color change of nanoparticles with/without viruses can be observed with a conventional optical microscope. The scattering light from single nanoparticle has the size‐dependent characteristics of wavelength and intensity variation, allowing for optically detecting nanoscale virus. By comparing optical images before and after attaching viruses, quantitative detection can be achieved with the virus concentrations from 1.0 × 102 to 1.0 × 106 PFU mL–1 and a detection limit of 1.0 × 102 PFU mL–1. The antibody‐modified array can specifically recognize influenza viruses in 15 min. The result provides a promising approach to detect diverse biological samples, including protein, exosomes, and platelet microparticle.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
