Abstract
A cobalt (II) oxide/carboxylic acid functionalized multiwalled carbon nanotube (CoO/COOH-MWNT) composite was fabricated for the biochemical detection of dopamine (DA). CoO particles were tethered to COOH-MWNTs by sonication. The current response versus different concentration was measured using cyclic voltammetry. Various parameters, including sonication time, pH, and loading were varied for the best current response. The composite with optimum current response was formed using a 30-min sonication time, at pH 5.0 and a 0.89 µg/mm2 loading onto the glassy carbon electrode surface. Good sensitivity with a limit of detection of 0.61 ± 0.03 μM, and dynamic range of 10–100 µM for DA is shown, applicable for neuroblastoma screening. The sensor was selective against ascorbic and uric acids.
Highlights
Neuroblastoma is a type of pediatric cancer that forms in the adrenal glands, which can be exhibited in the spine, chest, neck and abdomen
L-ascorbic acid, phosphate buffer solution (PBS) at pH 7.00 and uric acid were purchased from Sigma-Aldrich
Scheme 1 shows the electrochemical mechanism of DA on the working electrode surface corresponding to the two observed peaks in the cyclic voltammetry (CV) data
Summary
Neuroblastoma is a type of pediatric cancer that forms in the adrenal glands, which can be exhibited in the spine, chest, neck and abdomen. Multiple analytical approaches, such as UV-vis spectrophotometry, high-performance liquid chromatography, fluorescence spectrophotometry and electrochemical methods, have been applied to detect dopamine in environmental and biological samples [1,2,3,4,5]. Uric acid (UA), in particular, interferes with DA during electrochemical detection and the electrochemical approach becomes difficult [18,19,20,21,22]. To this end, Khamlichi et al [23] developed an.
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