Abstract
Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties, implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging agents, and as photosensitizers in cancer therapy. In this study, the influences of a cationic functionalized fullerene on cellular behavior of human colorectal cancer cell line (HT-29) were investigated. Results indicated that HT-29 treated with the studied compound showed a lower sensitivity but a significant impairment in migration and invasion by interfering with the activities of matrix metalloproteinases (MMP-2 and 9). The presence of fullerene also altered the capacity of adhesion-related proteins to perform their activity, thereby inducing dramatically adverse effects on the cell physiological functions such as cell adhesion. Thus, our study suggests that this compound is a new potential anti-metastatic effector and a therapeutic component for malignant colorectal cancer.
Highlights
Current status of anticancer chemotherapy of solid malignant tumors indicates the necessity for agents active against tumor metastases
The present study examined the hypothesis that derivative C60+ participates in colorectal cancer cell invasion
C60+ caused a statistically significant reduction of cell viability, as determined by the MTT test only at the highest dose tested, being the other dosages only marginally capable to influence HT-29 cell growth during the experiment. This result is consistent with unpublished data showing different degrees of cytotoxicity of this fullerene derivative in vitro on a number of tumor cell lines: MCF7 cells were sensitive to the cytotoxic effects [9], whereas other cell lines, e.g. MDA-MB231, were much less sensitive, as reported here for HT-29 cells
Summary
Current status of anticancer chemotherapy of solid malignant tumors indicates the necessity for agents active against tumor metastases. [60] Fullerene Derivative Reduces Invasion and Migration of HT-29 CRC Cells in Vitro at Dose Free of Significant Effects on Cell Survival”, Nano-Micro Lett.
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