Abstract
We report a 6-year-old girl with periodic adrenocorticotropin-antidiuretic hormone (ACTH-ADH) discharge syndrome who showed accelerated height growth without pubertal signs. The levels of insulin-like growth factor I (IGF-I) and sex steroids were elevated during the spurt. Although the mechanism of hypersecretion of these hormones could not be elucidated, we speculate that it was due to extreme stimulation of the pituitary-adrenal axis or other pathway which would induce excess of adrenal sex steroid during the attack.
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