Abstract
A case of systemic lupus erythematosus with portal hypertension due to multiple nodular hyperplasia of the liver was reported. A 30-year-old female with systemic lupus erythematosus for the past 7 years was admitted to Sapporo City General Hospital because of hematemesis. She had been receiving prednisolone (about 10mg/day, as a maintenance dose) for over 4 years. Physical examination showed severe anemia and marked splenomegaly. Endoscopic examination, computed tomography scan, echography and scintigraphy of her liver revealed esophageal varices due to portal hypertension.ON the 8th hospital day, she was subjectted to splenectomy and esophageal transection. The pressure of her potal vein was 27cmH2O in the operation. The surface of her liver was irregular shape. The surgical liver biopsy revealed multiple nodular hyperplasia of the liver. On the 23rd hospital day, she was died owing to the failure of the sutures and sepsis. The relation ships between multiple nodular hyperplasia of the liver and nRNP antibody was discussed.
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