Abstract
Purpose: To investigate the pathogenesis of a secondary iris cyst with an immunohistochemical method. Methods: Single observational case report. A pathologic specimen was obtained from a 5-year-old girl who was found to have a secondary iris cyst. She had a history of previous penetrating ocular trauma and subsequent cataract surgery and pupilloplasty. Immunohistochemical staining with cytokeratin (CK) 19 and CK3 was used. Results: After immunohistochemical staining, the inner wall showed positive staining for CK19, which is specific for limbal, peripheral cornea and conjunctival epithelium, and negative staining for CK3, which is specific for corneal epithelium. Conclusions: With the aid of immunohistochemical analysis, a conjunctival epithelial origin was indicated, and pupilloplasty was identified as the causal event of the iris cyst while the possibility of primary iris cyst was ruled out.
Highlights
Iris cysts can be classified as primary or secondary
After immunohistochemical staining, the inner wall showed positive staining for CK19, which is specific for limbal, peripheral cornea and conjunctival epithelium, and negative staining for CK3, which is specific for corneal epithelium
Experimental studies have shown that the introduction of either corneal or conjunctival epithelium into the anterior chamber can lead to cyst formation [3]
Summary
Iris cysts can be classified as primary or secondary. Primary cysts are thought to be of neuroepithelial origin, whereas secondary cysts may result from implantation, metastasis, parasites, or miotic therapy. Secondary iris cysts are usually associated with surgery or penetrating ocular injuries [1]. Secondary cysts are generally considered to be driven by epithelial downgrowth [2], the specific origin of the cyst in our case was difficult to differentiate on the basis of light and electron microscopic characteristics. We present a secondary iris cyst whose origin was presumed to be associated with pupilloplasty by pathologic examination and an immunohistochemical study
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