Abstract
Hepatocellular carcinoma (HCC) metastasizing to the skin is uncommon and carries a poor prognosis. The most frequent sites of skin metastasis are the face and scalp. Cutaneous metastatic lesions usually appear as nodules, but sometimes show a pyogenic granuloma-like morphology. We report a case of multiple skin metastases from HCC that resembled pyogenic granulomas, and showing HepPar1 as a specific marker of HCC. A key feature in this case was metastasis to the mandibular gingiva and digits. This case emphasizes the need to recognize that gingival and digital masses like benign or inflammatory lesions might represent an initial sign of HCC.
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