A CASE OF LATE SYPHILIS IN A PATIENT WITH PEMPHIGUS VULGARIS

Abstract

The objective. Decrease the number of diagnostic mistakes of pemphigus vulgaris and late forms of syphilis to improve quality of life and prevent premature death in patients with pemphigus vulgaris. Raise doctors’ awareness of the use of treponemal tests to clarify the diagnosis of late forms of syphilis. Materials and methods. The case of pemphigus vulgaris determined on the basis of clinical picture, anamnesis, cytological examination results is described. A concomitant pathology was diagnosed, i.e., late syphilis due to the complex of serological tests: nontreponemal and treponemal (Venereal Disease Research Laboratory test (VDRL), Enzyme-Linked Immuno Sorbent Assay (ELISA), T. pallidum Haemagglutination Assay (TP-HA), Fluorescent Treponemal Antibody Absorption test (FTA abs), ELISA-Different). Results. At dynamic supervision and inspection of the patient on pemphigus vulgaris and late syphilis on the basis of positive treponemal tests was revealed: ELISA sums. (IgG+IgM) – positive, high-quality TP-HA «4+» – positive; semi-quantitative TP-HA 1: 8 «2+» – positive; FTA abs «3+» – positive. To verify the diagnosis, a serum sample was examined by ELISA-Different method. Conclusions. Due to a wide range of serological research and consultation of related specialists, late syphilis was diagnosed in a pemphigus vulgaris patient.