Abstract
Oral intravascular papillary endothelial hyperplasia (IPEH) is an uncommon, reactive vascular lesion with no specific clinical features. A male patient presented with a hard, painless lesion with volumetric enlargement in the lower lip region developing over a period of 1 year. Apparently the lesion was not adhered to the deep tissues and was not associated with the epithelial tissue. Excisional biopsy revealed an occlusive thrombus in a vein lumen and proliferative endothelial cells forming capillaries or arterioles with papillary aspect. Immunohistochemical analysis showed positivity in vessels for CD31 and smooth muscle actin on the vascular wall. Based on the clinical and microscopic features, the final diagnosis was IPEH. Although common, this lesion is little known by dental practitioners and a detailed microscopic analysis is mandatory to distinguish IPEH of angiosarcoma and other vascular lesions.
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