Abstract
A calmodulin inhibitor, trifluoperazine (TFP), can block yeast-to-germ-tube morphogenesis of Candida albicans induced by N-acetyl-d-glucosamine at 37°C. Furthermore, the ionophore A23187 can also block germ tube formation, which can be reversed by Ca2+. This indicates the possible involvement of calcium and calmodulin in morphogenesis of C. albicans. During germ tube formation, there is a progressive increase in the rate of protein phosphorylation, which is completely absent in non-germinating cells (yeast form). Trifluoperazine can also inhibit this phosphorylation indicating that protein phosphorylation may also be involved in this process.
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