Abstract
In the USA alone, one in four people report having misused psychoactive drugs at some time and over 11% have an active problem. The combined approaches of molecular biology and psychopharmacology reveal that addictive drugs cause long-term changes in brain function and, as a result, addiction is beginning to be seen as a chronic, relapsing illness. As the underlying cellular changes become clearer, the prospects for developing better pharmacotherapeutic strategies are improving.
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