Abstract
Earlier isolated plant polyphenol PI, which is carcinostatic on mice implanted with Ehrlich carcinoma [S. Takeuchi et al., Agric. Biol. Chem., 50, 569 (1986)], showed transient, nonspecific, non-cytotoxic growth inhibition in vitro on both normal and malignant cells. Examination of its effects on alteration of native and TPA-induced in vitro phenotypes revealed that PI suppress both the plasmin and ODC activities of the cells that increase with spontaneous malignancy, and also the TPA-induced ODC activity increase. TPA-induced decrease of 125I-mEGF-binding ability was reversed by PI, to larger extent in the HeLa cells than in the untransformed RME-5–3–1 cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
