Abstract
THE ENDOMETRIUM of the mouse exhibits an apparently specific response to progesterone that consists primarily in hypertrophy of the stromal nuclei (Hooker, 1940,1945). Since the response to progesterone in this species is much simpler morphologically than the complex glandular changes in the rabbit, since the systemic dose required is less (0.125 mg. as compared with 0.5 mg.), and since the amount of tissue exposed to the hormone upon direct administration is necessarily small, local administration in the mouse offered promise of providing a highly sensitive method of assay. As will be described, the method proved feasible and regularly detects progesterone in an amount of 0.0002 μg. EXPERIMENTS Technique. To minimize variations in the test animals, all of the 200 mice used have been members of the highly inbred CHI strain of Strong (1942), maintained on a diet of Purina Fox Chow and water supplied ad libitum.
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