Abstract
Genetic modification (GM) offers an alternative strategy to conventional animal breeding. The present study was carried out to investigate the potential health effects of the consumption of growth hormone-transgenic triploid carp (GH-ttc) through a 90-day subchronic rodent feeding study. Wistar rats (n = 10/sex/group) were given formulated diets containing GH-ttc or non-GM carp at an incorporated rate of 2.5%, 5%, or 10% (w/w) for 90 days. An additional control group of rats (n = 10/sex/group) was fed a basic rodent diet. During the 90-day study, clinical observation, ophthalmic examination, body weight, and food intake were evaluated. At the end of the study, rats were killed, and the hematology, serum chemistry, urine test, necropsy, and histopathology were assessed. Compared with the non-GM carp and the basic control groups, no biologically significant differences were observed on clinical signs of toxicity, body weights, food intake, hematology, serum chemistry, urinalysis, organ weight, and histopathology on selected organs for the GH-ttc group. The results of this 90-day subchronic feeding study indicated that, at the dose level used in this study, consumption of GH-ttc showed no subchronic toxicity to Wistar rats.
Highlights
Fish constitutes a very important part of the diet in terms of both quantity and contribution to human nutritional requirements and is a major source of animal protein in most developing countries [1]
As indicated by the results of the PCR test, the growth hormone (GH) gene was present in the growth hormone-transgenic triploid carp (GH-ttc), while it was not detected in the non-genetic modification (GM) carp (Figure 1)
There were no significant differences in body weight between the GH-ttc group and the corresponding non-GM carp group
Summary
Fish constitutes a very important part of the diet in terms of both quantity and contribution to human nutritional requirements and is a major source of animal protein in most developing countries [1]. According to current projections, by 2030, the world population will exceed eight billion; fisheries and traditional aquaculture will be unable to meet the human demand for fish [2]. Using transgenic technology to produce fish strains with valuable traits may be a promising strategy to address this problem. The application of growth hormone (GH) treatment and altered GH gene expression in genetically modified fishes may increase aquaculture production and efficiency [3]. There are fewer moral reservations regarding genetic modification (GM) in fishes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
