A-28 | Prognostic Impact of Blood Glucose Level in Patients Undergoing PCI

Abstract

High blood glucose values at the time of percutaneous coronary intervention (PCI) may be due to poorly controlled diabetes mellitus (DM) or other conditions. We aimed at assessing the frequency and prognostic impact of high blood glucose values in patients undergoing PCI. Patients undergoing PCI at a large-volume tertiary-care center (Mount Sinai Hospital, New York) between 2012 and 2019 were stratified based on their blood glucose at time of PCI into 3 groups: normal (70-126 mg/dL), high (127-199 mg/dL), and very-high (≥200 mg/dL) values. Outcomes included all-cause death, myocardial infarction (MI), or stroke and major bleeding at 1-year after PCI. Among 16,193 included patients, 61% had normal, 26% high and 13% very-high blood glucose values. In these groups, 27%, 76% and 93% of patients had DM, respectively. All-cause death, MI, or stroke occurred more frequently with high (5.4%, HR 1.76, 95% CI 1.47 – 2.12) and very high blood glucose values (8.7%, HR 2.89, 95% CI 2.37 - 3.52) as compared to patients with normal values (3.1%, reference group). Similarly, there was a stepwise increase of major bleeding across the three groups (Figure). Among patients undergoing PCI, high and very high blood glucose levels were frequent, not always associated with known DM, and were related with significantly higher rates of complications at 1-year.