Abstract
Cell division cycle 25A (CDC25A), a member of the CDC25 family of phosphatases, is required for progression from G1 to the S phase of the cell cycle. CDC25A provides an essential function during early embryonic development in mice, suggesting that it plays an important role in growth and development. In this study, we used mathematical expectation (ME) methods to identify a 20-bp insertion/deletion (indel) polymorphism of CDC25A gene in Shaanbei White Cashmere (SBWC) goats. We also investigated the association between this 20-bp indel and growth-related traits in SBWC goats. Association results showed that the indel was related to growth traits (height at hip cross, cannon circumference, and cannon circumference index) in SBWC goats. The height at hip cross of individuals with insertion/insertion (II) genotype was higher than those with insertion/deletion (ID) genotype (); on the contrary, the cannon circumference and cannon circumference index of individuals with ID genotype were superior when compared with those with II genotype ( and ). These findings suggest that the 20-bp indel in the CDC25A gene significantly affects growth-related traits, and could be utilized as a candidate marker for marker-assisted selection (MAS) in the cashmere goat industry.
Highlights
Goat is one of the most important livestock species and the oldest economic domesticated species, being used for meat, milk, and cashmere all over the world
In order to improve the comprehensive economic benefits of Shaanbei White Cashmere (SBWC) goats, it is necessary to study the growth and development traits so that we are able to lay a foundation for vigorously developing the meat performance of cashmere goats
Our findings provide a basis for further research on the underlying causal mutation and suggest hypotheses for further studies leading to the application of marker-assisted selection (MAS) for goat breeding
Summary
Goat is one of the most important livestock species and the oldest economic domesticated species, being used for meat, milk, and cashmere all over the world. With the improvement of society, goat meat is gradually consumed by the masses because of its high protein, low fat, and low cholesterol (Mao et al, 2012). Because of the high quality of meat, SBWC goats have been the main economic variety in Yulin city, Shaanxi province. In order to improve the comprehensive economic benefits of SBWC goats, it is necessary to study the growth and development traits so that we are able to lay a foundation for vigorously developing the meat performance of cashmere goats
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