Abstract
Objective To study the feature of brain functional in front gyrus, anterior cingulate cortex and hippocampus of patients with generalized anxiety disorder (GAD). Methods 19 patients with GAD and 20 healthy volunteers were scanned on brain using proton magnetic resonance spectroscopic imaging (1H-MRS). The levels of Choline (Cho), Creatine (Cr), N-acetyl-aspartate(NAA) were measured in the frontal gyrus, anterior cingulate cortex and hippocampus of all subjects.The 1H-MRS data were compared between two groups. Results Compared with the healthy matched control, the levels of Cho(7.22±1.99), Cr(5.44±1.68), NAA(12.09±2.30)in right frontal gyrus white matter, the levels of Cho(9.89±2.40), Cr(8.59±1.71)in right anterior cingulate cortex and the levels of NAA in left anterior cingulate cortex were significantly high (P 0.05). Conclusion The brain substance metabolisms of the patients with GAD are abnormal and asymmetrical between left and right brain, especially occurred in right brain. Key words: 1H-Magnetic resonance spectroscopy; Generalized anxiety disorder; Frontal gyrus; Anterior cingulate cortex; Hippocampus
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