Abstract
The convenient synthesis of 9-hydroxy-9-(4-carboxyphenyl)fluorene and its application as a new linker for solid phase synthesis is reported. The loading of the resin-bound linker with carboxylic acids as well as the cleavage conditions were investigated. The release of the carboxylic acids from this system by treatment with acids is hampered due to the electron-withdrawing effect of the carboxamide group in the para position of the phenyl ring of the resin-bound linker.
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