90-P: KIR GENOTYPE DISTRIBUTION AMONG PATIENTS WITH MULTIPLE MYELOMA: HIGHER PREVALENCE OF KIR 2DS4 AND KIR 2DS5 GENES

Abstract

Aim Study KIR expression of NK cells in MM patients and in healthy controls, to check for any association between KIR genotypes and MM. Methods KIR genotype was analysed for 120 healthy Lebanese patients and 34 MM patients. using the KIR Genotyping SSP kit. Results The content of KIR genes ranged from 7 to 15 and as per Table 4, the AA, AB, and BB genotypes frequencies were, respectively, 38.24%, 47.06% and 14.71% with an A:B ratio of 1.62:1. [figure1]Table 2 shows the distribution of different KIR genotypes among the 120 healthy Lebanese controls. The content of KIR genes ranged from 6 to 15 and, as per Table 4, the AA, AB, and BB genotypes frequencies were, respectively, 42.5%, 50%, and 7.5% with an A:B ratio of 2.08:1.[figure2]Fig. 2 shows the distribution of different KIR genes among the 120 controls and the 34 MM patients. KIR 3DL2 KIR 3DL3, and KIR 3DP1∗003 were present in all individuals. KIR 2DS4∗001/002 and KIR 2DS5 were found to be significantly (with a p-value of 0.04 and 0.007, respectively) more prevalent among MM patients as compared to controls. Conclusions The interesting observation of the significant presence of KIR 2DS4 and KIR 2DS5 genes more among Multiple Myeloma than controls is worth further clinical and translational research in the future as well as correlation with outcome of bone marrow transplantation in these cases.