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Abstract

Introduction: Pancreatitis usually presents as a self limiting disease. In its severe form is complicated by multi system failure and has a high mortality. On the other hand, APACHE II score provides an objective assessment of severity of illness and Ranson criteria are used as an indicator assessing the systematic affects. Hypothesis: The aim of our study was to test the hypothesis that there is a difference among severity indexes like APACHE II score values, Ranson score, Glasgow Coma Scale (GCS) as well as length of stay (LOS) and vendilation days (VD) between patients with acute pancreatitis who died and patients with acute pancreatitis who survived ICU. Methods: From November 2005 to April 2012, 406 patients admitted to our ICU. From these, 11 (2.7 %) were indicated with the diagnosis of acute pancreatitis. The patients separated in two groups. In Group A involved 4 patients who survived ICU and in group B involved 7 patients who died. We looked for statistical significant difference (p value two tailed) between the medians values of two groups, using the unpaired Mann - Whithney test or the unpaired t test Welch corrected according to the normality test. Results: We detected no statistical difference between the two groups according: age (p=0.11), APACHE II score (p=0.65), Ranson score (p=0.93), GCS (p=0.96), LOS (p=0.21), VD (p=0.58), temperature (p=0.72), MAP (p=0.49), HR (p=0.68), Na (p=0.69), k (p=0.16), BUN (p=0.40), Cr (p=0.39), WBC (p=0.77), Ht (p=0.86), PaO2 (p=0.62), PH (p=0.36), albumine (p=0.95), glucose (p=0.99), Bilirubin (p=0.08), Ca (p=0.43), amylase (p=0.55). We detected statistical significant higher group B value according, PaCO2 (p=0.04), Conclusions: According to our data, there was no statistical difference detected between the two groups according to the severity indexes as well as to the allocating parameters. The only difference detected was that the patients who died (Group B), had a significant higher PaCO2 value (p=0.04). Our data suggest that patient who survived, had a better ability for respiratory compensation of metabolic acidosis, limiting the PH changes and perhaps, limiting the later multiple organ failure.