Abstract
For several tumour types it has been found that there is a correlation between clinical outcome and the relative number of tumour cells in S phase as measured with DNA flow cytometry (FCM). From data showing that a high S phase fraction is associated with poor prognosis it has been concluded that these tumours have a high proliferative activity and therefore grow faster. Moreover, the size of the S phase fraction has also been used as an equivalent of labelling index to determine tumour growth fraction in experimental cell kinetic studies. In the present study the relationship between DNA distribution and the duration ofcell cycle phases in tumours was investigated with the aid ofa computerized mathematical model. In our study we found poor correlation between the size of the S phase fraction and the proliferative activity when tumour growth fraction was taken into account. A shortening of the duration of the S phase ie, increased cell production per time unit, led to a decrease in the relative number of S phase cells as measured by FCM.
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