Abstract
YAP/TAZ are key molecules in the Hippo signaling pathway that regulate organ size and promote the development and progression of proliferative diseases such as tumors through the induction of cell growth and inhibition of apoptosis. Skin fibrosis is characterized by persistent proliferation of fibroblasts and excessive production of extracellular matrix. Given the key role of the Hippo signaling pathway in other cells, we speculate that YAP/TAZ may also be involved in the pathogenesis of fibrosis.
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