Abstract
Background: Solid tumors and rheumatoid arthritis have overlapping mechanisms of pathogenesis. Both diseases are characterized by a hyperproliferative component, hypoxia, excessive angiogenesis, and inflammation. First-line treatments also overlap. Examples are methotrexate and cyclophosphamide which are used to treat many different malignancies as well as being first-line treatments for rheumatoid arthritis. The hyperproliferative component of RA is the pannus, which is a fibroblastic mass that expands in the affected joint and provides a home to immune cells which produce inflammatory cytokines, much like the biology of the tumor extracellular matrix.
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