Abstract
As surgical and anesthetic techniques have evolved, perioperative mortality in complex cancer surgical interventions has decreased significantly. However, complications and associated morbidity remain a challenge not only for surgical recovery, but also for functional restoration, completion of care for the patient, and long-term cancer outcomes. As such, optimization and preparation for major cancer surgery (prehabilitation) should be a high priority safety initiative and a fundamental strategy in perioperative medicine. Appropriate preparative management or optimization of functional capacity prior to an anticipated stressor can mitigate adverse outcomes, which carry substantial clinical and economic implications. Pivotal strategies with substantial impact include hematological optimization (including the correction of iron deficiency and anemia), appropriate use of blood products, and prevention of thromboembolic complications.
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