Abstract
Dermal white adipose tissue (dWAT), a unique layer which is enriched with adipocytes, preadipocytes and adipocyte progenitors, is indispensable for maintaining skin homeostasis and tissue regeneration during skin wound healing. However, the origin, developmental path and the cellular complexity and plasticity of dWAT lineage cells remain poorly understood. Here, by single-cell RNA-seq (scRNA-seq) analyses of dermal cell populations isolated from mice at various post-developmental ages or at indicated post-wounding days, we have carried out in-depth analysis to define how dermal adipocytes are differentiated from their progenitors and to identify key signaling pathways that regulate dermal adipogenesis.
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