Abstract
Cytomegalovirus (CMV) infection is an established cause of morbidity and mortality in renal transplant recipients. CMV-seronegative (SN) recipients of allografts from seropositive donors appear to be particularly vulnerable to clinically apparent post-transplant CMV disease. Since CMV seropositivity increases with age, pediatric transplant candidates are a logical population in whom to consider establishment of pre-transplant immunity through vaccination. Results of a preliminary vaccine trial in 5 SN adult transplant candidates immunized with CMV Towne 125, an attenuated strain, are reported here. Antibody to CMV was detected by IFA 2-4 weeks after vaccination in all patients. No CMV was recovered from any patient, despite later immunosuppression. No vaccine-attributable clinical or laboratory abnormalities have occurred. Current status of vaccinees is as follows: Vaccination may offer a safe means of production of CMV antibody in renal transplant candidates at risk for CMV infection.
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