Abstract
Delayed or impaired wound healing in aging skin poses major medical, social, and economic challenges, yet a systematic understanding of the contributing cellular and molecular alterations is lacking. In this work, we use single-cell RNA sequencing to interrogate differences across epithelial, fibroblast, and immune cell types in the skin wounds of young and aged animals. We have identified major changes in their subset compositions and molecular profiles during wound healing. Our data uncover a more inflammatory phenotype in wounds from aged mice, featuring altered immune cell compositions and a previously unknown inflammatory Arg1Hi macrophage subset, compared to young counterparts.
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