Abstract
which, however, is mostly transient. When combined with X-irradiation, EGFR inhibition may lead to an enhanced permanent radiation-induced G1 arrest. This effect, however, only occurs in p53 wt cells with erlotinib being slightly more effective than BIBX. Increase in permanent G1 arrest is abolished when p21 is absent or knocked down. After EGFR inhibition increase in cellular radiosensitivity is also only found for cells which are p53 wt (A549) and not those, which are negative (FaDu, H1299). For A549 cells no radiosensitization after EGFR inhibition was seen, when increase in radiation-induced permanent G1 arrest was abolished. Conclusions: For tumor cells with wt p53, EGFR inhibition prior to irradiation increases permanent G1 arrest which contributes to an enhanced cellular radiosensitivity.
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