7187 Prospective analysis of the clinical features of patients with streaky erythema in the antrum: a negative endoscopic sign for helicobactor pyroli infection.

Abstract

[Background] We previously reported that H. pylori infection rate was extremely low in patients with streaky erythema (SE) in the antrum, which was an independent negative sign for H. pylori infection by logistic regression analysis. Then we conducted the present study to investigate prospectively the clinical features of patients with SE including H. pylori infection and other endoscopic findings. [Patients] The subjects were the consecutive 100 patients with SE undergoing endoscopy of the gastrointestinal tract since Oct 1998 to Aug 1999. The 85 age and gender-matched patients were employed as controls. [Results] The diagnostic tests for H. pylori infection were positive as following: 0% (0/85) of the patients with SE and 48% (41/85) of the control patients in rapid urease tests (p<0.01), 1.2% (1/84) and 48% (39/84) in culture of H. pylori (p<0.01), 1.5% (1/69) and 44% (35/69) in anti-H. pylori antibodies (p<0.01), 0% (0/21) and 52% (13/25) in 13C-urea breathing tests (p<0.05). Other endoscopic findings were as followings: gastric/duodenal ulcer (including scar) in 0% (0/85) of the patients with SE and 15% (13/85) of the controls (p<0.01), gastric cancer in 0% (0/85) and 1.2% (1/85), hyper plastic polyps in 0% (0/85) and 2.4% (2/85), fundic gland polyps in 13% (11/85) and 2.4% (2/85), erosions in 8.2% (7/85) and 14% (12/85) (p<0.01). [Conclusion] The infection rate of H. pylori in patients with SE was extremely low and they had rarely peptic ulcer diseases, but often had fundic gland polyps. [Background] We previously reported that H. pylori infection rate was extremely low in patients with streaky erythema (SE) in the antrum, which was an independent negative sign for H. pylori infection by logistic regression analysis. Then we conducted the present study to investigate prospectively the clinical features of patients with SE including H. pylori infection and other endoscopic findings. [Patients] The subjects were the consecutive 100 patients with SE undergoing endoscopy of the gastrointestinal tract since Oct 1998 to Aug 1999. The 85 age and gender-matched patients were employed as controls. [Results] The diagnostic tests for H. pylori infection were positive as following: 0% (0/85) of the patients with SE and 48% (41/85) of the control patients in rapid urease tests (p<0.01), 1.2% (1/84) and 48% (39/84) in culture of H. pylori (p<0.01), 1.5% (1/69) and 44% (35/69) in anti-H. pylori antibodies (p<0.01), 0% (0/21) and 52% (13/25) in 13C-urea breathing tests (p<0.05). Other endoscopic findings were as followings: gastric/duodenal ulcer (including scar) in 0% (0/85) of the patients with SE and 15% (13/85) of the controls (p<0.01), gastric cancer in 0% (0/85) and 1.2% (1/85), hyper plastic polyps in 0% (0/85) and 2.4% (2/85), fundic gland polyps in 13% (11/85) and 2.4% (2/85), erosions in 8.2% (7/85) and 14% (12/85) (p<0.01). [Conclusion] The infection rate of H. pylori in patients with SE was extremely low and they had rarely peptic ulcer diseases, but often had fundic gland polyps.