713 Regional chemotherapy in the combined treatment of rectal cancer

Abstract

Patients with rectal cancer (RC) were administered preoperative selective intraarterial polychemotherapy (IASP) in the combined treatment for maximum devitalization of tumor tissue and better survival. 135 patients (pt) were stratified into three groups: (1) surgery alone—75 pt, (2) systemic polychemotherapy prior to surgery—eight pt, (3) surgery after IASP—52 pt. Preoperative systemic polychemotherapy did not improve 3-year survival compared to patients treated with surgery alone. Selective IASP respectively with subsequent surgery improved 3-year survival by 13.6% (from 59.4 + 3.8% to 73.0 + 5%, P 0.05). Thus, IASP resulted in a significantly better prognosis for patients with RC compared to surgery alone and in combination with preoperative systemic polychemotherapy. Patients with rectal cancer (RC) were administered preoperative selective intraarterial polychemotherapy (IASP) in the combined treatment for maximum devitalization of tumor tissue and better survival. 135 patients (pt) were stratified into three groups: (1) surgery alone—75 pt, (2) systemic polychemotherapy prior to surgery—eight pt, (3) surgery after IASP—52 pt. Preoperative systemic polychemotherapy did not improve 3-year survival compared to patients treated with surgery alone. Selective IASP respectively with subsequent surgery improved 3-year survival by 13.6% (from 59.4 + 3.8% to 73.0 + 5%, P 0.05). Thus, IASP resulted in a significantly better prognosis for patients with RC compared to surgery alone and in combination with preoperative systemic polychemotherapy.