703 Blood analysis uncovers novel inflammatory, oncologic and cardiovascular biomarkers in psoriasis and Hidradenitis Suppurativa

Abstract

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease with manifestations ranging from nodules and abscesses to draining tunnels. Despite the significant morbidity associated with the disease, there is a lack of effective treatments and biomarkers of disease activity. To evaluate the serum proteomic signature of HS relative to other systemic skin diseases, we analyzed 1536 serum biomarkers using the OLINK high-throughput cardiovascular, neurology, oncology and inflammatory panels in moderate to severe HS (n=11), psoriasis (n=10) and healthy control volunteers (n=10). Overall, HS had >190 unique differentially expressed proteins (DEPs, abs(FCH)≥1.2, p≤0.05) relative to healthy controls whereas psoriasis had >55 DEPs relative to healthy controls. Both psoriasis and HS showed an increase of serum proteins related to multiple inflammatory pathways, however, there was a higher inflammatory burden associated with HS. Compared to age- and BMI-matched healthy controls, psoriasis and HS had an increase of atherosclerotic and cardiovascular biomarkers, with HS having a higher number of these biomarkers relative to psoriasis. Further analysis identified >40 biomarkers significantly (≤0.05) correlated with PASI score and >130 biomarkers significantly correlated with ISH4 scores. In HS, several biomarkers of atherosclerotic disease significantly correlated with ISH4 scores. This study was limited by inclusion of only moderate-severe psoriasis and HS patients. Our data suggests that HS has a distinct immune, cardiovascular/atherosclerotic and oncologic signature, which presents novel therapeutic avenues.