Abstract
Egress of lipoprotein-derived cholesterol from lysosomes requirestwo lysosomal proteins, polytopic membrane-bound Niemann–PickC1 (NPC1) and soluble Niemann–Pick C2 (NPC2). The reason for thisdual requirement is unknown. Previously, we showed that the solu-ble luminal N-terminal domain (NTD) of NPC1 (amino acids 25–264)binds cholesterol. This NTD is designated NPC1(NTD). We and othersshowed that soluble NPC2 also binds cholesterol. Here, we establishan
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