Abstract
We have previously demonstrated that herpes simplex virus (HSV) vector-mediated transfer to dorsal root ganglion (DRG) in vivo to effect the release of enkephalin or GABA provides significant analgesic effects in rodent models. Endomorphin-2 is a recently identified peptide with high affinity for the mu-opiate receptor. The gene coding for this amidated tetrapeptide has not been identified. In this study we sought to create a herpes simplex virus (HSV)-based gene transfer vector that would express endomorphin-2 and to examine its effect in models of neuropathic anti-inflammatory pain.
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