Abstract
Hypertrophic scars are a common complication of burn injury, yet there are no medications to prevent their formation. Myofibroblasts, a key cell involved in scar formation, are resistant to apoptosis. We have previously shown that hydroxypyridone anti-fungals can inhibit myofibroblast transformation in burn scar-derived fibroblasts. This study aimed to investigate if these drugs can target established myofibroblasts. Primary human dermal fibroblasts, derived from burn patient scars, were exposed to transforming growth factor beta-1 (TGF-β1) for 72 h to induce myofibroblast transformation.
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