Abstract
Two new δ-lactol derived chiral glycine equivalents have been prepared in one-pot processes in good yields from the known 6-methyltetrahydropyran-2-ol. Alkylation proceeds in moderate to good yields and moderate to good selectivities under experimentally simple conditions. The lactol chiral auxiliary is readily removed under mild acidic conditions to give N-Cbz protected alpha-amino amides in good yields.
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