Abstract
Nucleic acid aptamers are synthetic, short, single-stranded DNA or RNA molecules able to recognize and specifically bind to several targets including small molecules, cells, and whole organisms. Aptamers can be selected from a random-sequence oligonucleotide library by systematic evolution of ligands by exponential enrichment with specificity and affinity that are comparable to antibodies, presenting as a relevant research tool for disease investigation and a promising approach for therapy. In addition, because of their in vitro synthesis, oligonucleotide aptamers can easily be produced and modified to improve stability and pharmacokinetic properties. Several aptamer-based drug candidates are in clinical trial phases, which indicates their therapeutic potential.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Current Developments in Biotechnology and Bioengineering
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
