Abstract
ABSTRACT: Premature ventricular contraction (PVC) patients exhibit specific circadian patterns, yet the lack of circadian rhythm increases the risk of cardiomyopathy. To fully understand the three types of PVC circadian rhythms, we must therefore understand the mechanism of circadian variability, not just of PVC burden. Reflecting on 65 idiopathic PVC patients collecting saliva for cortisol and norepinephrine levels three times daily, undergoing a 24-hour Holter examination, and reporting their morning, afternoon, and evening self-rated health scales; this paper indicates pathways in which psycho-neuro-endocrine physiology and circadian variability in frequency of PVC burden are embodied. Higher cortisol levels and lower parasympathetic nervous system tone are at higher risk of higher burden of fast-type idiopathic PVC. Lower cortisol levels and lower sympathetic nervous system tone are at higher risk of higher burden of slow-type idiopathic PVC. Higher cortisol levels and sympathetic nervous system tone as well as lower self-rated health scales are at higher risk of higher burden of independent-type idiopathic PVC.
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