Abstract
Because of the unavailability of alternate methods to determine protein-loss, we measured the gastrointestinal clearance of alpha-1-antitrypsin (AAT), by a modification of a European technique. We studied eight patients, three with hypoalbuminemia and disorders suggestive of protein-losing enteropathy, and five with or without hypoalbuminemia and gastrointestinal disorders not necessarily associated with protein loss. Clearance of AAT was calculated from the following equation: CAAT = (FxV)/P where C is in cc/days; F = fecal concentration of AAT in cc/1; V = fecal volume in cc/day; P = serum AAT in mg/1. Stools were collected over a three day period and serum AAT obtained on each of three days and averaged in some patients, and from two or one specimen in other patients. The stool was homogenized, and a one gram aliquot resuspended in distilled water. AAT was measured by radioimmuno-diffusion using standard techniques. Serum AAT was measured by standard techniques.We conclude that a three day stool collection with determination of CAAT may be useful in identifying children with protein losing enteropathy.
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