508 Efficacité du traitement avec des acides gras essentiels omega-6 administrés avant et après la kératectomie photo réfractive

Abstract

Following PRK, a regression or the appearance of haze is often observed due to an anomalous response by the stroma, probably mediated by the keratocytes. Inhibiting the transmission of the apoptosis signal from the damaged corneal epithelium to the keratocytes can be achieved by using a systemic product that would control the release of the mediators of the inflammation and stimulate tear production. The aim of this prospective study is to test the effects of Medilar, a supplement containing linoleic and γ-linolenic acid, β-Carotene, group B vitamins and trace elements (copper, zinc), when administered both before and after PRK. Eighty subjects undergoing PRK were divided randomly into two groups. The group treated with Medilar included 18 females and 22 males, of an average age of 32 years ; the control group included 20 females and 20 males (average age 30 years). Statistical evaluation of the results was carried out on Schirmer test, on fluorescein staining values and on the state of the epithelium. In the Schirmer tests, comparison between the 2 groups of patients who underwent surgery (Groups 1 and 2) showed a statistically significant difference after 7, 15 and 30 days treatment in favour of the group treated with Medilar (p<0.05). The values related to the fluorescein staining test and the state of the epithelium showed a statistically significant difference in favour of the group treated with Medilar (p<0.001 and p<0.05, respectively). Controlling keratocyte apoptosis seems to affect the outcome and stability of PRK. This results would confirm the real advantages of using omega-3 essential fatty acids to optimise and stabilise the outcome of PRK.