Abstract
Serotonin (5-HT) agonists, selective for 5-HT 1, 5-HT 2 or 5-HT 3 receptor subtypes, were tested for their ability to mimic 5-HT in narrowing the tetraethylammonium-induced calcium-dependent plateau of action potentials recorded from frog sensory neuroons. 5-Carboxyamidotryptamine, 5-HT, α-methyl 5-HT and 5-methoxy-tryptamine possessed full agonist activity, with EC 50s of 19 nM, 210 nM, 3.7 μM, and 1.7 μM, respectively. 2-Methyl 5-HT was inactive. This agonist profile indicates that the calcium-dependent plateau in these sensory somata is modulated by a 5-HT 1-like receptor.
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