Abstract
NGS-based detection of TRG and TRB clonality has yet to be widely implemented in clinical laboratories. It offers clone tracking with high sensitivity, once clonality is established in an index sample. Across reported studies, no standard criteria have been established for calling clonality by TCR-seq. Thus, we describe our validation experience using the LymphoTrack TRG/TRB Assays - MiSeq (Invivoscribe, Inc.) where the LymphoTrack software was used to examine merged read frequencies of sequences with <2bp difference.
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